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EgyptAir Flight MS804 from Paris to Cairo 'disappears from radar'
EgyptAir says the plane disappeared about 10 miles (16km) into Egyptian air space and the relevant authorities have been notified.
The search operation is being co-ordinated with the Greek authorities.
In a later update, EgyptAir said that three children were among those on board the plane.
Aviation analyst Alex Macheras told the BBC that Airbus A320s were regularly used for short-haul budget flights and had "an amazing safety record".
The EgyptAir aircraft left Paris at 23:09 local time on Wednesday (21:09 GMT) and was scheduled to arrive in the Egyptian capital soon after 03:00 local time on Thursday.
In March, an EgyptAir plane was hijacked and diverted to Cyprus. The attacker later surrendered and all hostages were released.
Last October, a Russian passenger plane flying from Sharm el-Sheikh crashed over the Sinai peninsula killing all 224 people on board. Officials in Moscow later said the aircraft was brought down by an explosive device.
Islamic State militants said they had bombed the plane.